This is a bogus error screen that replaces your browser's home page. The message Reads:
Detected Spyware! System error #384
Your IP address is XX.XXX.XX.XX. Using this address a remote computer has gained access to your computer and probably is collecting the information about the sites you've visited and the files contained in the folder Temporary Internet Files. Attention! Ask for help of install the software for deleting secret information about the sites you visited.
You computer is full of evidences!
More than likely, this message is just the tip of the iceberg. Using simple intrusion detection tools you will see that your system has scores of viruses, trojans, worms and other malware installed on it. The message is trying to get you to purchase some scamware.
How to remove the “Detected Spyware! System error #384” message and all the malware on your system?
There are actually a few relatively easy ways for removing this malware:
USE FREE (LEGITIMATE) ANTI-SPYWARE
COMPLETELY RE-INSTALL WINDOWS (self explanatory, and complete overkill unless you have rootkit on your system or something crazy like that.)